اثرات تمرین هوازی، مقاومتی و ترکیبی بر سطوح آدیپونکتین و CTRP9 در بیماران مبتلا به دیابت میلیتوس نوع دو

1. Association AD. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes—2018. Diabetes care. 2018;41(Supplement_1):S13-S27.
2. Petersmann A, Müller-Wieland D, Müller UA, Landgraf R, Nauck M, Freckmann G, et al. Definition, classification and diagnosis of diabetes mellitus. Experimental and Clinical Endocrinology & Diabetes. 2019;127(S 01):S1-S7.
3. Khursheed R, Singh SK, Wadhwa S, Kapoor B, Gulati M, Kumar R, et al. Treatment strategies against diabetes: Success so far and challenges ahead. European journal of pharmacology. 2019;862:172625.
4. Balducci S, D’Errico V, Haxhi J, Sacchetti M, Orlando G, Cardelli P, et al. Effect of a behavioral intervention strategy on sustained change in physical activity and sedentary behaviorin patients with type 2 diabetes: the IDES_2 randomized clinical trial. Jama. 2019;321(9):880-90.
5. Teich T, Zaharieva DP, Riddell MC. Advances in exercise, physical activity, and diabetes mellitus. Diabetes Technology & Therapeutics. 2019;21(S1):S-112-S-22.
6. Cannata F, Vadalà G, Russo F, Papalia R, Napoli N, Pozzilli P. Beneficial effects of physical activity in diabetic patients. Journal of Functional Morphology and Kinesiology. 2020;5(3):70.
7. Jung C-H, Jung S-H, Kim B-Y, Kim C-H, Kang S-K, Mok J-O. Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a hospital-based study. Cardiovascular Diabetology. 2015;14(1):1-9.
8. Wang Y, Meng R-W, Kunutsor SK, Chowdhury R, Yuan J-M, Koh W-P, et al. Plasma adiponectin levels and type 2 diabetes risk: a nested case-control study in a Chinese population and an updated meta-analysis. Scientific reports. 2018;8(1):1-13.
9. Dimou NL, Papadimitriou N, Mariosa D, Johansson M, Brennan P, Peters U, et al. Circulating adipokine concentrations and risk of five obesity‐related cancers: A Mendelian randomization study. International journal of cancer. 2021;148(7):1625-36.
10. Zouhal H, Zare-Kookandeh N, Haghighi MM, Daraei A, de Sousa M, Soltani M, et al. Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications. Reviews in Endocrine and Metabolic Disorders. 2021:1-25.
11. Si Y, Fan W, Sun L. A review of the relationship between CTRP family and coronary artery disease. Current atherosclerosis reports. 2020;22(6):1-7.
12. Yu X-H, Zhang D-W, Zheng X-L, Tang C-K. C1q tumor necrosis factor-related protein 9 in atherosclerosis: mechanistic insights and therapeutic potential. Atherosclerosis. 2018;276:109-116.

13           Ahmed SF, Shabayek MI, Abdel Ghany ME, El-Hefnawy MH, El-Mesallamy HO. Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females. PLoS One. 2018;13(12):e0208038.

14. Moradi N, Fadaei R, Emamgholipour S, Kazemian E, Panahi G, Vahedi S, et al. Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease. PloS one. 2018;13(1):e0192159.
15. Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, et al. CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism. Journal of Biological Chemistry.2012;287 (23):18965-73.
16. Su H, Yuan Y, Wang X-M, Lau WB, Wang Y, Wang X, et al. Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice. Basic research in cardiology. 2013;108(1):1-12.

17..        Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, Wong GW. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2013;305(5):R522-R33.

18. Wolf RM, Jaffe AE, Rodriguez S, Lei X, Sarver DC, Straub AT, et al. Altered adipokines in obese adolescents: a cross-sectional and longitudinal analysis across the spectrum of glycemia. American Journal of Physiology-Endocrinology and Metabolism. 2021;320(6):E1044-E52.
19. Haase CL, Lopes S, Olsen AH, Satylganova A, Schnecke V, McEwan P. Weight loss and risk reduction of obesity-related outcomes in 0.5 million people: evidence from a UK primary care database. International Journal of Obesity. 2021;45(6):1249-58.
20. Ghanemi A, Melouane A, Yoshioka M, St-Amand J. Exercise and high-fat diet in obesity: Functional genomics perspectives of two energy homeostasis pillars. Genes. 2020;11(8):875.
21. Fajriyah N, Sudiana IK, Wahyuni ED. The effects from physical exercise on the blood glucose levels, HbA1c and quality of life of type 2 diabetes mellitus patients: A systematic review. Jurnal Ners. 2020;15(2):486-96.
22. Honda H, Igaki M, Komatsu M, Tanaka S-i. Effect of moderate-intensity seated exercise on the management of metabolic outcomes in hypertensive individuals with or without exercise habits. Journal of Exercise Science & Fitness. 2021;19(1):51-6.
23. Qadir R, Sculthorpe NF, Todd T, BrownEC. Effectiveness of resistance training and associated program characteristics in patients at risk for type 2 diabetes: a systematic review and meta-analysis. Sports medicine-open. 2021;7(1):1-15.
24. Tandon S, Ayis S, Hopkins D, Harding S, Stadler M. The impact of pharmacological and lifestyle interventions on body weight in people with type 1 diabetes: A systematic review and meta‐analysis. Diabetes, Obesity and Metabolism. 2021;23(2):350-62.
25. Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, Wang X, et al. C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arteriosclerosis, thrombosis, and vascular biology. 2011;31(11):2616-23.
26. Deng W, Li C, ZhangY, Zhao J, Yang M, Tian M, et al. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetology & metabolic syndrome. 2015;7(1):1-8.
27. Emamgholipour S, Moradi N, Beigy M, Shabani P, Fadaei R, Poustchi H, et al. The association of circulating levels of complement-C1q TNF-related protein 5 (CTRP5) with nonalcoholic fatty liver disease and type 2 diabetes: a case–control study. Diabetology & metabolic syndrome. 2015;7(1):1-12.
28. Park S-Y, Choi JH, Ryu HS, Pak YK, Park KS, Lee HK, et al. C1q tumor necrosis factor α-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. Journal of biological chemistry. 2009;284(41):27780-9.

29           Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, et al. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013;36(10):3321-7.

30. Haas AV, McDonnell ME. Pathogenesis of cardiovascular disease in diabetes. Endocrinology and Metabolism Clinics. 2018;47(1):51-63.
31. Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, et al. C1q/tumor necrosis factor–related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation. Circulation. 2013;128(11_suppl_1):S113-S20.
32. Jung CH, Lee MJ, Kang YM, Jang JE, Leem J, Lee YL, et al. Association of serum C1q/TNF-related protein-9 concentration with arterial stiffness in subjects with type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism. 2014;99(12):E2477-E84.
33. Jia Y, Luo X, Ji Y, Xie J, Jiang H, Fu M, et al. Circulating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance. Diabetes research and clinical practice. 2017;131:116-23.
34. Asada M, Morioka T, Yamazaki Y, Kakutani Y, Kawarabayashi R, Motoyama K, et al. Plasma C1q/TNF-related protein-9levels are associated with atherosclerosis in patients with type 2 diabetes without renal dysfunction. Journal of diabetes research. 2016;2016.
35. Wolf RM, Steele KE, Peterson LA, Zeng X, Jaffe AE, Schweitzer MA, et al. C1q/TNF-related protein-9 (CTRP9)levels are associated with obesity and decrease following weight loss surgery. The Journal of Clinical Endocrinology & Metabolism. 2016;101(5):2211-7.
36. Becic T, Studenik C, Hoffmann G. Exercise increases adiponectin and reduces leptin levels in prediabetic and diabetic individuals: systematic review and meta-analysis of randomized controlled trials. Medical sciences. 2018;6(4):97.
37. García-Hermoso A, Ramírez-Vélez R, Ramírez-Campillo R, Peterson MD, Martínez-Vizcaíno V. Concurrent aerobic plus resistance exercise versus aerobic exercise alone to improve health outcomes in paediatric obesity: a systematic review and meta-analysis. British Journal of Sports Medicine. 2018;52(3):161-6.
38. Schwingshackl L, Dias S, Strasser B, Hoffmann G. Impact of different training modalities on anthropometric and metabolic characteristics in overweight/obese subjects: a systematic review and network meta-analysis. PloS one. 2013;8(12):e82853.
39. Schwingshackl L, Missbach B, Dias S, König J, Hoffmann G. Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis. Diabetologia. 2014;57(9):1789-97.
40. Lim K, Kim K, Lim K, Kim K. Role of Exercise-induced Adiponectin Activation on Obese and Diabetic Individuals. Exercise Science. 2020;29(3):208-13.
41. Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of exercise increases plasma adiponectin and release from adipose tissue. Medicine and science in sports and exercise. 2015;47(11):2450.
42. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European journal of Endocrinology. 2007;157(5):625-32.
43. Ring-Dimitriou S, Paulweber B, vonDuvillard SP, Stadlmann M, LeMura LM, Lang J, et al. The effect of physical activity and physical fitness on plasma adiponectin in adults with predisposition to metabolic syndrome. European journal of applied physiology. 2006;98(5):472-81.
44. KlimcakovaE, Polak J, Moro C, Hejnova J, Majercik M, Viguerie N, et al. Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. The Journal of Clinical Endocrinology & Metabolism. 2006;91(12):5107-12.
45. Balsan GA, Vieira JLdC, Oliveira AMd, Portal VL. Relationship between adiponectin, obesity and insulin resistance. Revista da Associação Médica Brasileira. 2015;61:72-80.
46. Richter EA, Mikines K, Galbo H, Kiens B. Effect of exercise on insulin action in human skeletal muscle. Journal of applied physiology. 1989;66(2):876-85.
47. Santos J, Ribeiro S, Gaya A, Appell H-J, Duarte J. Skeletal muscle pathways of contraction-enhanced glucose uptake. International journal of sports medicine. 2008;29(10):785-94.
48. Rutter GA, da Silva Xavier G, Leclerc I. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochemical Journal. 2003;375(1):1-16.
49. Wu S, Zou M-H. AMPK, mitochondrialfunction, and cardiovascular disease. International journal of molecular sciences. 2020;21(14):4987.