دانشگاه شهید مدنی آذربایجان

 آمار

تعداد نشریات6
تعداد شماره‌ها129
تعداد مقالات1,609
تعداد مشاهده مقاله1,831,937
تعداد دریافت فایل اصل مقاله1,701,573
رستمی, نگار, افرونده, رقیه, سیفی, فرناز, پوررحیم, آمنه. (1405). تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی. , 13(1), 144-155. doi: 10.22049/jahssp.2025.30394.1723
نگار رستمی; رقیه افرونده; فرناز سیفی; آمنه پوررحیم. "تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی". , 13, 1, 1405, 144-155. doi: 10.22049/jahssp.2025.30394.1723
رستمی, نگار, افرونده, رقیه, سیفی, فرناز, پوررحیم, آمنه. (1405). 'تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی', , 13(1), pp. 144-155. doi: 10.22049/jahssp.2025.30394.1723
رستمی, نگار, افرونده, رقیه, سیفی, فرناز, پوررحیم, آمنه. تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی. , 1405; 13(1): 144-155. doi: 10.22049/jahssp.2025.30394.1723

تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی

مطالعات کاربردی تندرستی در فیزیولوژی ورزش
مقاله 18، دوره 13، شماره 1، فروردین 1405، صفحه 144-155    اصل مقاله (704.92 K)
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
شناسه دیجیتال (DOI): 10.22049/jahssp.2025.30394.1723
نویسندگان
نگار رستمی* 1؛ رقیه افرونده2؛ فرناز سیفی3؛ آمنه پوررحیم4
1گروه فیزیولوژی ورزشی،دانشکده علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل،ایران
2دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران
33. دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.
42. استادیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.
چکیده
هدف: آسیب ایسکمی/ خون‌رسانی مجدد میوکارد (MI/RI) یکی از عوامل تعیین‌کننده اختلالات بیماری‌های قلبی عروقی می‌باشد که با مرگ سلولی ناشی از التهاب و اختلال در فعالیت پروتئین‎های دیوبی‌کوئیتینه کننده همراه است. هدف از مطالعه حاضر تعیین تأثیر تمرین هوازی تناوبی بر بیان پروتئین‌های A20 و CYLD در بافت قلب موش‌های نر مدل سکته قلبی بود. روش پژوهش: در مطالعه تجربی حاضر 30 سر موش صحرایی نر نژاد ویستار 16 هفته‌ای با وزن 220 تا 280 گرم به‌طور تصادفی به سه گروه کنترل (سالم)، انفارکتوس میوکارد (MI) و MI+تمرین هوازی تناوبی با شدت متوسط تقسیم شدند. انفارکتوس میوکارد توسط مداخله مستقیم با بستن LAD به مدت‌30 دقیقه انجام شد. پروتکل تمرین هوازی تناوبی با شدت متوسط 60 دقیقه دویدن تناوبی روی تردمیل، هر تناوب شامل 4 دقیقه دویدن با شدت 65 -70 درصد VO2max و 2 دقیقه بازیافت فعال با شدت 50 –60 درصد VO2max، ‌ سه روز در هفته و به مدت 8 هفته انجام شد. به‌منظور بررسی بیان پروتئین‌های A20 و CYLD از روش وسترن بلات استفاده شد. داده‌ها با استفاده از آنالیز واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معنی‌داری 05/0>p مقایسه شدند.. یافته‌ها: نتیجه آزمون تعقیبی توکی برای متغیر A20 نشان داد که میزان بیان این پروتئین در گروه MI به‌طور معنی‌داری پایین‌تر از گروه کنترل سالم بود (01/0=p). همچنین، میزان بیان پروتئین A20 در گروه تمرین+MI به‌طور معنی‌داری نسبت به گروه MI و کنترل سالم افزایش داشت (به ترتیب:  001/0=p، 03/0=p). نتایج نشان داد هرچند میزان بیان پروتئین CYLD در گروه MI نسبت به گروه کنترل سالم کاهش یافت؛ اما ازنظر آماری معنی‌دار نبود (06/0=p). همچنین، میزان بیان پروتئین CYLD در گروه تمرین+MI نسبت به گروه کنترل سالم و MI افزایش یافت (به ترتیب:  01/0=p، 001/0=p). نتیجه‌گیری: تمرین هوازی تناوبی احتمالاً با افزایش پروتئین‌های A20 و CYLD قلبی و کاهش التهاب، از مرگ سلولی ناشی از آن جلوگیری می‌کند. بااین‌حال، به دلیل کمبود شواهد و محدودیت‌های تحقیق، همچنان نیازمند بررسی‌های بیشتر می‌باشد.
کلیدواژه‌ها
تمرین هوازی تناوبی؛ سکته قلبی؛ A20؛ CYLD قلبی
مراجع
  1. Ibáñez B, Heusch G, Ovize M, Van de Werf F. Evolving therapies for myocardial ischemia/reperfusion injury. Journal of the American College of Cardiology. 2015;65(14):1454-71.
  2. Costa MA, Paiva AE, Andreotti JP, Cardoso MV, Cardoso CD, Mintz A, et al. Pericytes constrict blood vessels after myocardial ischemia. Journal of molecular and cellular cardiology. 2018;116:1-4.
  3. Thind GS, Agrawal PR, Hirsh B, Saravolatz L, Chen-Scarabelli C, Narula J, et al. Mechanisms of myocardial ischemia–reperfusion injury and the cytoprotective role of minocycline: scope and limitations. Future cardiology. 2015;11(1):61-76.
  4. Li B, Xie X. A20 (TNFAIP3) alleviates viral myocarditis through ADAR1/miR-1a-3p-dependent regulation. BMC Cardiovascular Disorders. 2022;22(1):10.
  5. Wang H, Lai Y, Mathis BJ, Wang W, Li S, Qu C, et al. Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. Journal of molecular and cellular cardiology. 2015;84:143-53.
  6. Zhan X, Yang Y, Li Q, He F. The role of deubiquitinases in cardiac disease. Expert Reviews in Molecular Medicine. 2024;26:e3.
  7. Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, et al. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature. 2015;528(7582):370-5.
  8. Lawless D, Pathak S, Scambler TE, Ouboussad L, Anwar R, Savic S. A case of adult-onset Still’s disease caused by a novel splicing mutation in TNFAIP3 successfully treated with tocilizumab. Frontiers in Immunology. 2018;9:1527.
  9. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, et al. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nature immunology. 2015;16(6):618-27.
  10. Osório J. A20–NEMO interaction prevents autoinflammation. Nature Reviews Rheumatology. 2016;12(3):134-.
  11. Priem D, Devos M, Druwé S, Martens A, Slowicka K, Ting AT, et al. A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and-independent mechanisms. Cell death & disease. 2019;10(10):692.
  12. Li H-L, Zhuo M-L, Wang D, Wang A-B, Cai H, Sun L-H, et al. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation. 2007;115(14):1885-94.
  13. Han D, Fang W, Zhang R, Wei J, Kodithuwakku ND, Ma W, et al. Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20. Brain, behavior, and immunity. 2016;51:56-69.
  14. Zhang R, Xu L, Zhang D, Hu B, Luo Q, Han D, et al. Cardioprotection of ginkgolide B on myocardial ischemia/reperfusion-induced inflammatory injury via regulation of A20-NF-κB pathway. Frontiers in Immunology. 2018;9:2844.
  15. Yan K, Ponnusamy M, Xin Y, Wang Q, Li P, Wang K. The role of K63‐linked polyubiquitination in cardiac hypertrophy. Journal of Cellular and Molecular Medicine. 2018;22(10):4558-67.
  16. Ji Y-X, Huang Z, Yang X, Wang X, Zhao L-P, Wang P-X, et al. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nature medicine. 2018;24(2):213-23.
  17. Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, et al. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nature immunology. 2020;21(6):626-35.
  18. Xie W, Gao S, Yang Y, Li H, Zhou J, Chen M, et al. CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart. Cell Reports. 2022;41(13).
  19. Huang Z, Tan Y. The potential of cylindromatosis (CYLD) as a therapeutic target in oxidative stress-associated pathologies: a comprehensive evaluation. International Journal of Molecular Sciences. 2023;24(9):8368.
  20. Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, et al. Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. Biochemical and Biophysical Research Communications. 2019;508(4):1168-74.
  21. Klaeske K, Dix M, Adams V, Jawad K, Eifert S, Etz C, et al. Differential regulation of myocardial E3 ligases and deubiquitinases in ischemic heart failure. Life. 2021;11(12):1430.
  22. Bi H-L, Zhang X-L, Zhang Y-L, Xie X, Xia Y-L, Du J, et al. The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. Science advances. 2020;6(16):eaax4826.
  23. Zhang DH, Zhang JL, Huang Z, Wu LM, Wang ZM, Li YP, et al. Deubiquitinase ubiquitin‐specific protease 10 deficiency regulates Sirt6 signaling and exacerbates cardiac hypertrophy. Journal of the American Heart Association. 2020;9(22):e017751.
  24. Gao H, Li Z, Gan L, Chen X. The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling. Journal of Cardiovascular Translational Research. 2024;17(4):923-34.
  25. Moraes-Silva IC, Rodrigues B, Coelho-Junior HJ, Feriani DJ, Irigoyen M-C. Myocardial infarction and exercise training: evidence from basic science. Exercise for Cardiovascular Disease Prevention and Treatment: From Molecular to Clinical, Part 1. 2017:139-53.
  26. Li S, Qian X, Gong J, Chen J, Tu W, Chen X, et al. Exercise training reverses lipotoxicity-induced cardiomyopathy by inhibiting HMGCS2. Medicine and science in sports and exercise. 2021;53(1):47-57.
  27. Lin Y-Y, Hong Y, Zhou M-C, Huang H-L, Shyu W-C, Chen J-S, et al. Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats. Journal of Applied Physiology. 2020;128(4):1033-43.
  28. Zhang J, Huang C, Meng X, Xu K, Shi Y, Jiang L, et al. Effects of different exercise interventions on cardiac function in rats with myocardial infarction. Heart, Lung and Circulation. 2021;30(5):773-80.
  29. Maillet M, Van Berlo JH, Molkentin JD. Molecular basis of physiological heart growth: fundamental concepts and new players. Nature reviews Molecular cell biology. 2013;14(1):38-48.
  30. Gao R, Wang L, Bei Y, Wu X, Wang J, Zhou Q, et al. Long Noncoding RNA Cardiac Physiological Hypertrophy–Associated Regulator induces cardiac physiological hypertrophy and promotes functional recovery after myocardial ischemia-reperfusion injury. Circulation. 2021;144(4):303-17.
  31. Hamidian, Gholamreza, Piralai, Elahe, Rashvan Esmaeil, Badrkhan, Mehri Rokh, Zahra. The effect of aerobic exercise combined with cranberry fruit hydro-alcoholic extract supplementation on oxidative stress and antioxidant defense system in the heart tissue of desert rats. Metabolism and Exercise, 1403; 14(1): 185-204. doi: (in persian).10.22124/jme.2024.27061.353
  32.  
  33. Costa MA, Paiva AE, Andreotti JP, Cardoso MV, Cardoso CD, Mintz A, et al. Pericytes constrict blood vessels after myocardial ischemia. Journal of molecular and cellular cardiology. 2018;116:1-4.
  34. Thind GS, Agrawal PR, Hirsh B, Saravolatz L, Chen-Scarabelli C, Narula J, et al. Mechanisms of myocardial ischemia–reperfusion injury and the cytoprotective role of minocycline: scope and limitations. Future cardiology. 2015;11(1):61-76.
  35. Li B, Xie X. A20 (TNFAIP3) alleviates viral myocarditis through ADAR1/miR-1a-3p-dependent regulation. BMC Cardiovascular Disorders. 2022;22(1):10.
  36. Wang H, Lai Y, Mathis BJ, Wang W, Li S, Qu C, et al. Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. Journal of molecular and cellular cardiology. 2015;84:143-53.
  37. Zhan X, Yang Y, Li Q, He F. The role of deubiquitinases in cardiac disease. Expert Reviews in Molecular Medicine. 2024;26:e3.
  38. Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, et al. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature. 2015;528(7582):370-5.
  39. Lawless D, Pathak S, Scambler TE, Ouboussad L, Anwar R, Savic S. A case of adult-onset Still’s disease caused by a novel splicing mutation in TNFAIP3 successfully treated with tocilizumab. Frontiers in Immunology. 2018;9:1527.
  40. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, et al. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nature immunology. 2015;16(6):618-27.
  41. Osório J. A20–NEMO interaction prevents autoinflammation. Nature Reviews Rheumatology. 2016;12(3):134-.
  42. Priem D, Devos M, Druwé S, Martens A, Slowicka K, Ting AT, et al. A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and-independent mechanisms. Cell death & disease. 2019;10(10):692.
  43. Li H-L, Zhuo M-L, Wang D, Wang A-B, Cai H, Sun L-H, et al. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation. 2007;115(14):1885-94.
  44. Han D, Fang W, Zhang R, Wei J, Kodithuwakku ND, Ma W, et al. Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20. Brain, behavior, and immunity. 2016;51:56-69.
  45. Zhang R, Xu L, Zhang D, Hu B, Luo Q, Han D, et al. Cardioprotection of ginkgolide B on myocardial ischemia/reperfusion-induced inflammatory injury via regulation of A20-NF-κB pathway. Frontiers in Immunology. 2018;9:2844.
  46. Yan K, Ponnusamy M, Xin Y, Wang Q, Li P, Wang K. The role of K63‐linked polyubiquitination in cardiac hypertrophy. Journal of Cellular and Molecular Medicine. 2018;22(10):4558-67.
  47. Ji Y-X, Huang Z, Yang X, Wang X, Zhao L-P, Wang P-X, et al. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nature medicine. 2018;24(2):213-23.
  48. Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, et al. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nature immunology. 2020;21(6):626-35.
  49. Xie W, Gao S, Yang Y, Li H, Zhou J, Chen M, et al. CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart. Cell Reports. 2022;41(13).
  50. Huang Z, Tan Y. The potential of cylindromatosis (CYLD) as a therapeutic target in oxidative stress-associated pathologies: a comprehensive evaluation. International Journal of Molecular Sciences. 2023;24(9):8368.
  51. Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, et al. Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis. Biochemical and Biophysical Research Communications. 2019;508(4):1168-74.
  52. Klaeske K, Dix M, Adams V, Jawad K, Eifert S, Etz C, et al. Differential regulation of myocardial E3 ligases and deubiquitinases in ischemic heart failure. Life. 2021;11(12):1430.
  53. Bi H-L, Zhang X-L, Zhang Y-L, Xie X, Xia Y-L, Du J, et al. The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. Science advances. 2020;6(16):eaax4826.
  54. Zhang DH, Zhang JL, Huang Z, Wu LM, Wang ZM, Li YP, et al. Deubiquitinase ubiquitin‐specific protease 10 deficiency regulates Sirt6 signaling and exacerbates cardiac hypertrophy. Journal of the American Heart Association. 2020;9(22):e017751.
  55. Gao H, Li Z, Gan L, Chen X. The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling. Journal of Cardiovascular Translational Research. 2024;17(4):923-34.
  56. Moraes-Silva IC, Rodrigues B, Coelho-Junior HJ, Feriani DJ, Irigoyen M-C. Myocardial infarction and exercise training: evidence from basic science. Exercise for Cardiovascular Disease Prevention and Treatment: From Molecular to Clinical, Part 1. 2017:139-53.
  57. Li S, Qian X, Gong J, Chen J, Tu W, Chen X, et al. Exercise training reverses lipotoxicity-induced cardiomyopathy by inhibiting HMGCS2. Medicine and science in sports and exercise. 2021;53(1):47-57.
  58. Lin Y-Y, Hong Y, Zhou M-C, Huang H-L, Shyu W-C, Chen J-S, et al. Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats. Journal of Applied Physiology. 2020;128(4):1033-43.
  59. Zhang J, Huang C, Meng X, Xu K, Shi Y, Jiang L, et al. Effects of different exercise interventions on cardiac function in rats with myocardial infarction. Heart, Lung and Circulation. 2021;30(5):773-80.
  60. Maillet M, Van Berlo JH, Molkentin JD. Molecular basis of physiological heart growth: fundamental concepts and new players. Nature reviews Molecular cell biology. 2013;14(1):38-48.
  61. Gao R, Wang L, Bei Y, Wu X, Wang J, Zhou Q, et al. Long Noncoding RNA Cardiac Physiological Hypertrophy–Associated Regulator induces cardiac physiological hypertrophy and promotes functional recovery after myocardial ischemia-reperfusion injury. Circulation. 2021;144(4):303-17.
  62. Soltani N, Marandi SM, Kazemi M, Esmaeil N. Combined all-extremity high-intensity interval training regulates immunometabolic responses through toll-like receptor 4 adaptors and A20 downregulation in obese young females. Obesity Facts. 2020;13(3):415-31.
  63. Fukuda S, Kaga S, Sasaki H, Zhan L, Zhu L, Otani H, et al. Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. Journal of molecular and cellular cardiology. 2004;36(4):547-59.
  64. Li F, Zhan Z, Qian J, Cao C, Yao W, Wang N. Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy. Experimental and therapeutic medicine. 2021;22(2):811.
  65. Ebadi B, Naderi N, Darbandi Azar A, Damirchi A. Interval intensity Exercise improves the levels of Mitophagy-related proteins and ROS in rats with myocardial infarction. Journal of Exercise and Health Science. 2021;1(2):19-34.
  66. Pouzesh Jadidi, G., Seifi-Skishahr, F., Bolboli, L., Azali Alamdari, K., Pourrahim Ghouroghch, A. Effect of high intensity interval training and curcumin supplementation on left ventricular of miR-133 and miR-1 gene expression in isoproterenol-induced myocardial infarction rat model. Journal of Practical Studies of Biosciences in Sport, 2023; 11(25): 8-20. [In Persian]
  67. Wu Y, Pan N, An Y, Xu M, Tan L, Zhang L. Diagnostic and prognostic biomarkers for myocardial infarction. Frontiers in cardiovascular medicine. 2021;7:617277.
  68. Kraljevic J, Marinovic J, Pravdic D, Zubin P, Dujic Z, Wisloff U, et al. Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart. Cardiovascular research. 2013;99(1):55-64.
  69. Rodrigues B, Figueroa DM, Mostarda CT, Heeren MV, Irigoyen M-C, De Angelis K. Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats. Cardiovascular diabetology. 2007;6:1-7.
  70. Liou C-M, Tsai S-C, Kuo C-H, Ting H, Lee S-D. Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse. International journal of molecular sciences. 2014;15(4):5988-6001.
  71. Ye B, Chen Y, Chen X, Xu D, Jiang Y, Lin W, et al. Deubiquitinase USP25 alleviates obesity-induced cardiac remodeling and dysfunction by downregulating TAK1 and reducing TAK1-mediated inflammation. JACC: Basic to Translational Science. 2024.
  72. Gong Y, Yu T, Shuai W, Chen T, Zhang J, Huang H. USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice. Molecular Medicine. 2023;29(1):157.
  73. Han J, Lin L, Fang Z, Ye B, Han X, Xu J, et al. Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21. Theranostics. 2024;14(16):6236.
  74. Liu Y, Wang M, Liang Y, Wang C, Naruse K, Takahashi K. Treatment of oxidative stress with exosomes in myocardial ischemia. International journal of molecular sciences. 2021;22(4):1729.
  75. Han W, Wang W, Wang Q, Maduray K, Hao L, Zhong J. A review on regulation of DNA methylation during post-myocardial infarction. Frontiers in Pharmacology. 2024;15:1267585.
  76. Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, et al. Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clinical epigenetics. 2017;9:1-9.
  77. Newton K, Gitlin AD. Deubiquitinases in cell death and inflammation. Biochemical Journal. 2022;479(10):1103-19.
  78. Chen J, Kos R, Garssen J, Redegeld F. Molecular insights into the mechanism of necroptosis: the necrosome as a potential therapeutic target. Cells. 2019;8(12):1486.
  79. He F, Li J, Liu Z, Chuang C-C, Yang W, Zuo L. Redox mechanism of reactive oxygen species in exercise. Frontiers in physiology. 2016;7:486.
  80. Zheng G, Qiu P, Xia R, Lin H, Ye B, Tao J, et al. Effect of aerobic exercise on inflammatory markers in healthy middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials. Frontiers in aging neuroscience. 2019;11:98.
  81. Snyder NA, Silva GM. Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response. Journal of Biological Chemistry. 2021;297(3).
  82.  
  83. Fukuda S, Kaga S, Sasaki H, Zhan L, Zhu L, Otani H, et al. Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. Journal of molecular and cellular cardiology. 2004;36(4):547-59.
  84. Li F, Zhan Z, Qian J, Cao C, Yao W, Wang N. Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy. Experimental and therapeutic medicine. 2021;22(2):811.
  85. Ebadi B, Naderi N, Darbandi Azar A, Damirchi A. Interval intensity Exercise improves the levels of Mitophagy-related proteins and ROS in rats with myocardial infarction. Journal of Exercise and Health Science. 2021;1(2):19-34.
  86. Pouzesh Jadidi, G., Seifi-Skishahr, F., Bolboli, L., Azali Alamdari, K., Pourrahim Ghouroghch, A. Effect of high intensity interval training and curcumin supplementation on left ventricular of miR-133 and miR-1 gene expression in isoproterenol-induced myocardial infarction rat model. Journal of Practical Studies of Biosciences in Sport, 2023; 11(25): 8-20. [In Persian]
  87. Wu Y, Pan N, An Y, Xu M, Tan L, Zhang L. Diagnostic and prognostic biomarkers for myocardial infarction. Frontiers in cardiovascular medicine. 2021;7:617277.
  88. Kraljevic J, Marinovic J, Pravdic D, Zubin P, Dujic Z, Wisloff U, et al. Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart. Cardiovascular research. 2013;99(1):55-64.
  89. Rodrigues B, Figueroa DM, Mostarda CT, Heeren MV, Irigoyen M-C, De Angelis K. Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats. Cardiovascular diabetology. 2007;6:1-7.
  90. Liou C-M, Tsai S-C, Kuo C-H, Ting H, Lee S-D. Cardiac Fas-dependent and mitochondria-dependent apoptosis after chronic cocaine abuse. International journal of molecular sciences. 2014;15(4):5988-6001.
  91. Ye B, Chen Y, Chen X, Xu D, Jiang Y, Lin W, et al. Deubiquitinase USP25 alleviates obesity-induced cardiac remodeling and dysfunction by downregulating TAK1 and reducing TAK1-mediated inflammation. JACC: Basic to Translational Science. 2024.
  92. Gong Y, Yu T, Shuai W, Chen T, Zhang J, Huang H. USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice. Molecular Medicine. 2023;29(1):157.
  93. Han J, Lin L, Fang Z, Ye B, Han X, Xu J, et al. Cardiomyocyte-derived USP28 negatively regulates antioxidant response and promotes cardiac hypertrophy via deubiquitinating TRIM21. Theranostics. 2024;14(16):6236.
  94. Liu Y, Wang M, Liang Y, Wang C, Naruse K, Takahashi K. Treatment of oxidative stress with exosomes in myocardial ischemia. International journal of molecular sciences. 2021;22(4):1729.
  95. Han W, Wang W, Wang Q, Maduray K, Hao L, Zhong J. A review on regulation of DNA methylation during post-myocardial infarction. Frontiers in Pharmacology. 2024;15:1267585.
  96. Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, et al. Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clinical epigenetics. 2017;9:1-9.
  97. Newton K, Gitlin AD. Deubiquitinases in cell death and inflammation. Biochemical Journal. 2022;479(10):1103-19.
  98. Chen J, Kos R, Garssen J, Redegeld F. Molecular insights into the mechanism of necroptosis: the necrosome as a potential therapeutic target. Cells. 2019;8(12):1486.
  99. He F, Li J, Liu Z, Chuang C-C, Yang W, Zuo L. Redox mechanism of reactive oxygen species in exercise. Frontiers in physiology. 2016;7:486.
  100. Zheng G, Qiu P, Xia R, Lin H, Ye B, Tao J, et al. Effect of aerobic exercise on inflammatory markers in healthy middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials. Frontiers in aging neuroscience. 2019;11:98.
  101. Snyder NA, Silva GM. Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response. Journal of Biological Chemistry. 2021;297(3).
 

آمار
تعداد مشاهده مقاله: 374
تعداد دریافت فایل اصل مقاله: 159


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب