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رستمی, نگار, افرونده, رقیه, سیفی, فرناز, پوررحیم, آمنه. (1405). تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی. , 13(1), 144-155. doi: 10.22049/jahssp.2025.30394.1723
نگار رستمی; رقیه افرونده; فرناز سیفی; آمنه پوررحیم. "تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی". , 13, 1, 1405, 144-155. doi: 10.22049/jahssp.2025.30394.1723
رستمی, نگار, افرونده, رقیه, سیفی, فرناز, پوررحیم, آمنه. (1405). 'تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی', , 13(1), pp. 144-155. doi: 10.22049/jahssp.2025.30394.1723
رستمی, نگار, افرونده, رقیه, سیفی, فرناز, پوررحیم, آمنه. تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی. , 1405; 13(1): 144-155. doi: 10.22049/jahssp.2025.30394.1723

تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی

مطالعات کاربردی تندرستی در فیزیولوژی ورزش
مقاله 18، دوره 13، شماره 1، فروردین 1405، صفحه 144-155    اصل مقاله (704.92 K)
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
شناسه دیجیتال (DOI): 10.22049/jahssp.2025.30394.1723
نویسندگان
نگار رستمی* 1؛ رقیه افرونده2؛ فرناز سیفی3؛ آمنه پوررحیم4
1گروه فیزیولوژی ورزشی،دانشکده علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل،ایران
2دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران
33. دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.
42. استادیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.
چکیده
هدف: آسیب ایسکمی/ خون‌رسانی مجدد میوکارد (MI/RI) یکی از عوامل تعیین‌کننده اختلالات بیماری‌های قلبی عروقی می‌باشد که با مرگ سلولی ناشی از التهاب و اختلال در فعالیت پروتئین‎های دیوبی‌کوئیتینه کننده همراه است. هدف از مطالعه حاضر تعیین تأثیر تمرین هوازی تناوبی بر بیان پروتئین‌های A20 و CYLD در بافت قلب موش‌های نر مدل سکته قلبی بود. روش پژوهش: در مطالعه تجربی حاضر 30 سر موش صحرایی نر نژاد ویستار 16 هفته‌ای با وزن 220 تا 280 گرم به‌طور تصادفی به سه گروه کنترل (سالم)، انفارکتوس میوکارد (MI) و MI+تمرین هوازی تناوبی با شدت متوسط تقسیم شدند. انفارکتوس میوکارد توسط مداخله مستقیم با بستن LAD به مدت‌30 دقیقه انجام شد. پروتکل تمرین هوازی تناوبی با شدت متوسط 60 دقیقه دویدن تناوبی روی تردمیل، هر تناوب شامل 4 دقیقه دویدن با شدت 65 -70 درصد VO2max و 2 دقیقه بازیافت فعال با شدت 50 –60 درصد VO2max، ‌ سه روز در هفته و به مدت 8 هفته انجام شد. به‌منظور بررسی بیان پروتئین‌های A20 و CYLD از روش وسترن بلات استفاده شد. داده‌ها با استفاده از آنالیز واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معنی‌داری 05/0>p مقایسه شدند.. یافته‌ها: نتیجه آزمون تعقیبی توکی برای متغیر A20 نشان داد که میزان بیان این پروتئین در گروه MI به‌طور معنی‌داری پایین‌تر از گروه کنترل سالم بود (01/0=p). همچنین، میزان بیان پروتئین A20 در گروه تمرین+MI به‌طور معنی‌داری نسبت به گروه MI و کنترل سالم افزایش داشت (به ترتیب:  001/0=p، 03/0=p). نتایج نشان داد هرچند میزان بیان پروتئین CYLD در گروه MI نسبت به گروه کنترل سالم کاهش یافت؛ اما ازنظر آماری معنی‌دار نبود (06/0=p). همچنین، میزان بیان پروتئین CYLD در گروه تمرین+MI نسبت به گروه کنترل سالم و MI افزایش یافت (به ترتیب:  01/0=p، 001/0=p). نتیجه‌گیری: تمرین هوازی تناوبی احتمالاً با افزایش پروتئین‌های A20 و CYLD قلبی و کاهش التهاب، از مرگ سلولی ناشی از آن جلوگیری می‌کند. بااین‌حال، به دلیل کمبود شواهد و محدودیت‌های تحقیق، همچنان نیازمند بررسی‌های بیشتر می‌باشد.
کلیدواژه‌ها
تمرین هوازی تناوبی؛ سکته قلبی؛ A20؛ CYLD قلبی
مراجع
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