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تاثیر تمرین تناوبی شدید و مصرف کورکومین بر سطوح تروپونین I و کراتین کیناز سرمی موشهای نر تیمار شده با ایزوپرترنول | ||
مطالعات کاربردی تندرستی در فیزیولوژی ورزش | ||
مقاله 6، دوره 8، شماره 1، فروردین 1400، صفحه 44-53 اصل مقاله (6.47 M) | ||
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I | ||
شناسه دیجیتال (DOI): 10.22049/jahssp.2021.27276.1358 | ||
نویسندگان | ||
امیر داداش زاده1؛ رقیه پوزش جدیدی* 2 | ||
1دانشجوی کارشناسی ارشد، گروه تربیت بدنی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران. | ||
2استادیار ، گروه تربیت بدنی،دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران. | ||
چکیده | ||
هدف: فعالیت بدنی منظم میتواند در پیشگیری و بازتوانی بیماریهای قلبی- عروقی مؤثر واقع شود. با این حال، اثر ترکیبی تمرین تناوبی شدید و مصرف مکمل کورکومین بر فاکتورهای آسیب قلبی درک نشده است؛ هدف از این تحقیق تعیین تاثیر تمرین تناوبی شدید و مصرف کورکومین بر سطوح تروپونین I و کراتین کیناز سرمی موشهای نر تیمار شده با ایزوپرترنول بود. روش شناسی: تعداد 40 سر موش صحرائی نر با تزریق درون صفاقی ایزوپرترنول(با دوز 100 میلیگرم بر هر کیلوگرم وزن بدن در دو روز متوالی) دچار انفاکتوس میوکارد شدند و به طور تصادفی در چهار گروه تمرین، مکمل کورکومین، توام (تمرین و مکمل کورکومین) و کنترل قرار گرفتند. در گروه تمرین، برنامه تمرینی با تناوب 4 دقیقه دویدن و سپس 2 دقیقه ریکاوری فعال به ترتیب با شدت 90-85 و 60 – 50 درصد VO2maxبود؛ که 60 دقیقه در یک روز؛ 5 بار در هفته به مدت هشت هفته انجام شد. در گروه مکمل، کورکومین روزانه 15 میلیگرم به ازای هر کیلوگرم وزن بدن به صورت گاواژ خوراکی استفاده شد. سطوح CK-MBوcTnI سرمی به روش الایزا اندازهگیری شدند. برای تجزیهوتحلیل دادهها از آزمون آماری آنوای یکطرفه استفاده شد. یافتهها: فقط مداخلات کورکومین و توام موجب کاهش معنیداری در سطوح cTnI سرمی شد (04/0P= و 001/0P=) تمرین به تنهایی تاثیری نداشت (44/0P=). همچنین، فقط تاثیر کورکومین و توام (کورکومین و تمرین تناوبی شدید) موجب کاهش معنیدار سطوح CK-MB شدند(002/0P= و 008/0P=). با این وجود، تمرین تناوبی شدید به تنهایی تاثیری معنیداری بر سطوح سرمی CK-MB نداشت (27/0P=). نتیجهگیری: بنابر نتایج تحقیق تمرین تناوبی شدید احتمالا باعث افزایش نشانگرهای آسیب قلبی (تروپونین I و کراتین کیناز) میشود و کورکومین قادر است تاحدودی نشانگرهای آسیب قلبی را کاهش دهد، اما به دلیل محدودیتها و کمبود شواهد در جمعیت سکته قلبی، هنوز به بررسیهای بیشتری نیاز است. | ||
کلیدواژهها | ||
تروپونین؛ تمرین تناوبی شدید؛ کورکومین؛ کراتین کیناز | ||
مراجع | ||
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