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Alameri, Ameer A., Lihumis, Hala, Mubarak, Hayfaa A., Aowda, Saadon Abdulla. (1402). Synthesis and Evaluation of Biological and Antioxidant Activity for Mefenamic Drug Derivativesof Some New Heterocyclic Compounds. , 2(1), 1-18. doi: 10.22049/cic.2023.28017.1027
Ameer A. Alameri; Hala Shkyair Lihumis; Hayfaa A. Mubarak; Saadon Abdulla Aowda. "Synthesis and Evaluation of Biological and Antioxidant Activity for Mefenamic Drug Derivativesof Some New Heterocyclic Compounds". , 2, 1, 1402, 1-18. doi: 10.22049/cic.2023.28017.1027
Alameri, Ameer A., Lihumis, Hala, Mubarak, Hayfaa A., Aowda, Saadon Abdulla. (1402). 'Synthesis and Evaluation of Biological and Antioxidant Activity for Mefenamic Drug Derivativesof Some New Heterocyclic Compounds', , 2(1), pp. 1-18. doi: 10.22049/cic.2023.28017.1027
Alameri, Ameer A., Lihumis, Hala, Mubarak, Hayfaa A., Aowda, Saadon Abdulla. Synthesis and Evaluation of Biological and Antioxidant Activity for Mefenamic Drug Derivativesof Some New Heterocyclic Compounds. , 1402; 2(1): 1-18. doi: 10.22049/cic.2023.28017.1027

Synthesis and Evaluation of Biological and Antioxidant Activity for Mefenamic Drug Derivativesof Some New Heterocyclic Compounds

Communications In Catalysis
دوره 2، شماره 1، مرداد 2023، صفحه 1-18    اصل مقاله (1.17 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22049/cic.2023.28017.1027
نویسندگان
Ameer A. Alameri* 1؛ Hala Shkyair Lihumis1؛ Hayfaa A. Mubarak1؛ Saadon Abdulla Aowda2
1Department of Chemistry, Faculty of science, University Babylon, Babylon, Iraq
2Department of Chemistry, College of science ,University of Babylon , Babylon, Iraq
چکیده
New heterocyclic derivatives were created in this investigation.The most readily accessible Mefenamic acid (M) was combined with thionyl chloride to produce (M1 compound).After treating the (M1) compound with hydrazinecarboxamide to obtain the (M2) derivative, the compound (M2) was subjected to a ring closer reaction with NaOH solution to obtain the 1,2,4-triazole-3-ol ring compound (M3). Compound (M) was reacted with phenyl hydrazine hydrate to produce (M4), and then a ring closer reaction was performed in basic medium with carbon disulfide and hydrazine hydrate to produce (M5).The chemical (M1) was reacted with 3-aminopropanoic acid to produce (M6).To obtain the oxazin ring, (M7) molecule was synthesized by treating (M6) compound with benzaldehyde in the presence of acetic anhydride (M7 compound). The biological and antioxidant activity of the prepared compounds (M1-M7) was studied by (DPPH) method, and the results were good compared to the standard ascorbic acid.
کلیدواژه‌ها
Mefenamic acid؛ Hydrazinecarboxamide؛ Phenylhydrazine؛ Oxazin؛ Antioxidant activity
مراجع
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