اثر هشت هفته تمرین تناوبی شدید و تداومی با شدت متوسط بر بیان ژن SIRT3 و HSP70 بافت قلب رت‌های نر نژاد اسپراگ-داولی چاق شده با غذای پر چرب و مبتلا به دیابت

1. Dastah, Samaneh, Babaei Bonab, Solmaz. The effect of exercise in water on the amount of Fetuin-A, ANGPTL4 and FGF21 in the serum of obese women with type 2 diabetes. Applied health studies in exercise physiology, 2021; 8(2): 51-60. doi: 10.22049/jahssp.2021.27436.1390

2. Segula D. Complications of obesity in adults: a short review of the literature. Malawi Med J. 2014;26(1):20–4.
3. Oraii A, Shafiee A, Jalali A, Alaeddini F, Saadat S, Masoudkabir F, et al. Prevalence, awareness, treatment, and control of type 2 diabetes mellitus among the adult residents of tehran: Tehran Cohort Study. BMC Endocr Disord. 2022;22(1):1–15.
4. Davari F, Alimanesh Z, Alimanesh Z, Salehi O, Hosseini SA. Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats. Arch Physiol Biochem. 2020;1–6.
5. Sharafi Dehrhm F, Soori R, Rastegar MM M, Sadegh A. The effect of high intensity interval training on muscular biomarkers of mitochondrial biogenesis in male rats. J Babol Univ Med Sci. 2017;19(6):57–63. [In Persian]

Nikozadeh, Alireza, Pozesh Jadidi, Ruqieh, Noorazar, Mir Alireza, Asgharpour Arshad, Masoud, Bashiri, Jabbar. The interactive effect of aerobic exercise and curcumin supplementation on mitochondrial NRF-1 and NRF-2 gene expression in cardiomyocytes of male rats model of myocardial infarction. Applied health studies in exercise physiology, 2021; 8(2): 44-50. doi: 10.22049/jahssp.2021.27321.1370

Dadrass A, Mohamadzadeh Salamat K, Hamidi K, Azizbeigi K. Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial. Journal of Diabetes & Metabolic Disorders. 2019;18:323-31.[In Persian]

Fathi I, Nourshahi M, Haghparast A, Fallahi HH. Effect of eight-week aerobic continuous and high intensity interval training on levels of SIRT3 in skeletal muscle tissue of Wistar rats. JSEP. 2015; 1277-1289. [In Persian]

Hodge T, Starnes J, Feger B, Hixson L, Harris MB. Effects of exercise and body temperature on eNOS, SIRT1, SIRT3 and Hsp70 expression in rat plantaris muscles (1164.6). FASEB J. 2014;28:1164–6.

Tashakori Zade M, Mogharnasi M. A study of the effect of 10 weeks of resistance training on HSP70 and insulin resistance in type 2 diabetic women. J Sport Biosci. 2016;8(3):341–51. [In Persian]

Nameni F. The Effect of a Single Bout Endurance Training on HSP70. World Appl Sci J. 2012;19(2):211–4.

Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward III JL, et al. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle. Aging (Albany NY). 2009;1(9):771.

Saremi A. Sporting exercises and diabetes mellitus type 2: a review on evidences. Cell and Tissue. 2011; 2(3): 171-181. [In Persian]

Huynh FK, Muoio DM, Hirschey MD. SIRT3 directs carbon traffic in muscle to promote glucose control. Diabetes. 2015;64(9):3058–60.

Tabari E, Mohebbi H, Karimi P, Moghaddami K, Khalafi M. The effects of interval training intensity on skeletal muscle pgc-1α in type2 diabetic male rats. Iran J Diabetes Metab. 2019;18(4):179–88. [In Persian]

Davari F, Alimanesh Z, Alimanesh Z, Salehi O, Hosseini SA. Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats. Arch Physiol Biochem. 2022;128(5):1215–20.

Zanjirian Z, Sarir H, Mohammadnia Ahmadi M. Effect of Continuous Exercise Training on Protein Levels of SIRT3 and OGG1 in the Liver Tissue of Male Wistar Rats. J Ilam Univ Med Sci. 2019;27(5):97–107. [In Persian]

Lanza IR, Short DK, Short KR, Raghavakaimal S, Basu R, Joyner MJ, et al. Endurance exercise as a countermeasure for aging. Diabetes 2008; 57: 2933–2942. Diabetes. 2012;61(10):2653.

Gurd BJ, Holloway GP, Yoshida Y, Bonen A. In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase–independent manner. Metabolism. 2012;61(5):733–41.

Asadi RHK, Arshadi S, Far AAB, Rasouli MH. The effect of 12-week aerobic trainings on mitochondrial biogenesis indicators in skeletal muscle among male rats. Majallah-i pizishki-i Danishgah-i Ulum-i Pizishki va Khadamat-i Bihdashti-i Darmani-i Tabriz. 2020;42(3):348–55. [In Persian]

Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K. Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. J Appl Physiol. 2010;109(2):332–40.

Shi T, Wang F, Stieren E, Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem. 2005;280(14):13560–7.

Sharifi E, Askari R, Haghighi AH. Comparision the effects of high and average intensity combined training on levels of serum heat shock proteins 70 and glycemic control in obese women with type 2 diabetes. Jundishapur Sci Med J. 2017;16(2):255–65. [In Persian]

Kandi Asadi RH, Arshadi S, Banaei Far AA, Rasouli MH. The effect of 12-week aerobic trainings on mitochondrial biogenesis indicators in skeletal muscle among male rats. Med J Tabriz Univ Med Sci Heal Serv. 2020;42(3): 348-355. [In Persian]

Pouzesh Jadidi G, Seify F, Bolboli L, Pourrahim A. Effect of high intensity interval training on cardiomyocytes HSP70 and Caspase-3 gene expression levels in myocardial infarction male rat model. J Appl Heal Stud Sport Physiol. 2022;9(2):1–11. [In Persian]

Abdollahi S, Mohamadzadeh SK, Azizbeigi K, Etemad Z. The Effect of aerobic training and octopamine on HSP70 and Caspase-3 protein expression in brown adipose tissue in rats received deeply heated oil treatment. 2020; 8(1): 48-59. [In Persian]

Sulzbacher MM, Ludwig MS, Heck TG. Oxidative stress and decreased tissue HSP70 are involved in the genesis of sepsis: HSP70 as a therapeutic target. Rev Bras Ter intensiva. 2020;32:585–91.

Szyller J, Bil-Lula I. Heat shock proteins in oxidative stress and ischemia/reperfusion injury and benefits from physical exercises: A review to the current knowledge. Oxid Med Cell Longev. 2021;2021.