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رحیمی, محمد رحمان, فرجی, حسن, رحیمی, لیلا. (1403). تاثیر مکمل HMB بر شاخص‌های آسیب عضلانی و ترکیب بدنی پس از فعالیت‌های ورزشی: مطالعه فراتحلیل. , 11(1), 53-66. doi: 10.22049/jahssp.2023.28612.1553
محمد رحمان رحیمی; حسن فرجی; لیلا رحیمی. "تاثیر مکمل HMB بر شاخص‌های آسیب عضلانی و ترکیب بدنی پس از فعالیت‌های ورزشی: مطالعه فراتحلیل". , 11, 1, 1403, 53-66. doi: 10.22049/jahssp.2023.28612.1553
رحیمی, محمد رحمان, فرجی, حسن, رحیمی, لیلا. (1403). 'تاثیر مکمل HMB بر شاخص‌های آسیب عضلانی و ترکیب بدنی پس از فعالیت‌های ورزشی: مطالعه فراتحلیل', , 11(1), pp. 53-66. doi: 10.22049/jahssp.2023.28612.1553
رحیمی, محمد رحمان, فرجی, حسن, رحیمی, لیلا. تاثیر مکمل HMB بر شاخص‌های آسیب عضلانی و ترکیب بدنی پس از فعالیت‌های ورزشی: مطالعه فراتحلیل. , 1403; 11(1): 53-66. doi: 10.22049/jahssp.2023.28612.1553

تاثیر مکمل HMB بر شاخص‌های آسیب عضلانی و ترکیب بدنی پس از فعالیت‌های ورزشی: مطالعه فراتحلیل

مطالعات کاربردی تندرستی در فیزیولوژی ورزش
مقاله 5، دوره 11، شماره 1، فروردین 1403، صفحه 53-66    اصل مقاله (1.28 M)
نوع مقاله: مقاله مروری Released under (CC BY-NC 4.0) license I Open Access I
شناسه دیجیتال (DOI): 10.22049/jahssp.2023.28612.1553
نویسندگان
محمد رحمان رحیمی1؛ حسن فرجی* 2؛ لیلا رحیمی3
1گروه فیزیولوژی ورزشی، دانشگاه کردستان، سنندج، ایران
2دانشگاه آزاد اسلامی، واحد مریوان، گروه تربیت بدنی، مریوان، ایران
3آموزش و پرورش سنندج
چکیده
هدف: در این فراتحلیل اثر مکمل بتا هیدروکسی متیل بوتیرات (HMB) بر آسیب عضلانی و شاخص­های ترکیب بدنی بررسی شد. روش شناسی: جستجوی سیستماتیک از پایگاه های اطلاعاتی PubMed، Google scholar، Sciencedirect ، SID ، Scopus، IranMedex، Irandoc انجام گرفت تمام کارآزمایی های بالینی کنترل شده تصادفی، که به مصرف مکمل HMB بر شاخص های کراتین کیناز (CK)، لاکتات دهیدروژناز (LDH) و شاخص های ترکیب بدنی، توده چربی (FM)، توده بدون چربی (FFM) و جرم بدن (BM) انتخاب شدند. مدل‌های اثرات ثابت و تصادفی برای فراتحلیل اندازه اثر متوسط (اختلاف در میانگین با فاصله اطمینان 95 درصد)، در پژوهش مربوط به کراتین کیناز (16 پژوهش)، لاکتات دهیدروژناز (14 پژوهش)، توده چربی بدن (17 پژوهش)، توده بدون چربی بدن (20 پژوهش) و وزن بدن (23 پژوهش) به کمک نرم افزار CMA2 انجام شد. یافته‌ها: نتایج فراتحلیل نشان داد که مصرف مکمل  HMB باعث کاهش معنی­دار CK (22/0-=ES، 86/-0 تا 41/0=95% CI، 034/0=p) ، LDH (34/0=ES، 31/0 تا 57/0=% CI95، 022/0=p) و FM (43/0-=ES، 74/0- تا 119/0- =% CI 95، 007/0=p) گردید و با افزایش معنی­دار FFM (31/0-=ES، 007/0 تا 61/0=% CI 95، 045/0=p) همراه بوده است، اما تاثیری بر BM (054/0=ES، 09/0- تا 20/0=% CI 95، 46/0=p) نداشت. نتیجه‌گیری: به طور کلی نتایج فراتحلیل نشان داد که مکمل سازی مزمن HMB باعث کاهش معنادار آنزیم های شاخص آسیب عضلانی مانند CK، LDH بعد از ورزش می شود و همچنین با کاهش معنی دار FM و افزایش FFM همراه بوده است.
کلیدواژه‌ها
آسیب عضلانی؛ بتا هیدروکسی بتا متیل بوتیرات؛ کراتین کیناز؛ لاکتات دهیدروژناز؛ ترکیب بدن
مراجع
  1. Brancaccio P, Lippi G, Maffulli N. Biochemical markers of muscular damage. Clinical chemistry and laboratory medicine. 2010;48(6):757-67.
  2. Kirby TJ, Triplett NT, Haines TL, Skinner JW, Fairbrother KR, McBride JM. Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise. Amino acids. 2012;42(5):1987-96.
  3. . Eslami R, Abnama N. Short Term HMB-FA Supplementation Decreases Muscle Damage Markers After Soccer Matches. Research in Sport Medicine & Technology.2023;20(24):89-102. [In Persian]
  4. Popovic LM, Mitic NR, Radic I, Miric D, Kisic B, Krdzic B, et al. The effect of exhaustive exercise on oxidative stress generation and antioxidant defense in guinea pigs. Advances in Clinical and Experimental Medicine. 2012;21(3):313-20.
  5. Van Koevering M, Nissen S. Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo. American Journal of Physiology-Endocrinology And Metabolism. 1992;262(1):E27-E31.
  6. He X, Duan Y, Yao K, Li F, Hou Y, Wu G, et al. β-Hydroxy-β-methylbutyrate, mitochondrial biogenesis, and skeletal muscle health. Amino Acids. 2016;48(3):653-64.
  7. Slater GJ, Jenkins D. β-Hydroxy-β-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Medicine. 2000;30(2):105-16.
  8. Smith HJ, Wyke SM, Tisdale MJ. Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by β-hydroxy-β-methylbutyrate. Cancer research. 2004;64(23):8731-5.
  9. Panton LB, Rathmacher JA, Baier S, Nissen S. Nutritional supplementation of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) during resistance training. Nutrition. 2000;16(9):734-9.
  10. Nissen S, Sharp R, Ray M, Rathmacher J, Rice D, Fuller Jr J, et al. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. Journal of Applied Physiology. 1996.
  11. Pierno S, De Luca A, Tricarico D, Roselli A, Natuzzi F, Ferrannini E, et al. Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers. Journal of Pharmacology and Experimental Therapeutics. 1995;275(3):1490-6.
  12. Kreider R, Ferreira M, Wilson M, Almada A. Effects of calcium â-Hydroxy-â-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength. International journal of sports medicine. 1999;20(08):503-9.
  13. Slater G, Jenkins D, Logan P, Lee H, Vukovich M, Rathmacher JA, et al. β-hydroxy-β-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. International journal of sport nutrition and exercise metabolism. 2001;11(3):384-96.
  14. Wilson JM, Kim J-s, Lee S-r, Rathmacher JA, Dalmau B, Kingsley JD, et al. Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage. Nutrition & metabolism. 2009;6(1):1-8.
  15. Paddon-Jones D, Keech A, Jenkins D. Short-term B-hydroxy-B-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage. Int J Sport Nutr Exerc Metab. 2001;11(4):442-50.
  16. Knitter A, Panton L, Rathmacher J, Petersen A, Sharp R. Effects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged run. Journal of Applied Physiology. 2000;89(4):1340-4.
  17. Rowlands DS, Thomson JS. Effects of β-hydroxy-β-methylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: A meta-analysis. The Journal of Strength & Conditioning Research. 2009;23(3):836-46.
  18. Sanchez-Martinez J, Santos-Lozano A, Garcia-Hermoso A, Sadarangani KP, Cristi-Montero C. Effects of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in trained and competitive athletes: A meta-analysis of randomized controlled trials. Journal of Science and Medicine in Sport. 2018;21(7):727-35.
  19. Silva VR, Belozo FL, Micheletti TO, Conrado M, Stout JR, Pimentel GD, et al. β-Hydroxy-β-methylbutyrate free acid supplementation may improve recovery and muscle adaptations after resistance training: A systematic review. Nutrition research. 2017;45:1-9.
  20. Fernández-Landa J, Calleja-González J, León-Guereño P, Caballero-García A, Córdova A, Mielgo-Ayuso J. Effect of the combination of creatine monohydrate plus HMB supplementation on sports performance, body composition, markers of muscle damage and hormone status: A systematic review. Nutrients. 2019;11(10):2528.
  21. Schmidt R, Lee T. Motor learning and performance 6th edition with web study guide-loose-leaf edition: From principles to application: Human Kinetics Publishers; 2019.
  22. Jakubowski JS, Nunes EA, Teixeira FJ, Vescio V, Morton RW, Banfield L, et al. Supplementation with the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) does not improve resistance exercise-induced changes in body composition or strength in young subjects: a systematic review and meta-analysis. Nutrients. 2020;12(5):1523.
  23. Nissen SL, Sharp RL. Effect of dietary supplements on lean mass and strength gains with resistance exercise: a meta-analysis. Journal of Applied Physiology. 2003;94(2):651-9.
Radaei, Zainab, Shameshki, Afsana, Samadi, Ali. The effect of eight weeks of speed interval training (SIT) on the oxidant/antioxidant status of the heart tissue of male Wistar rats fed a high-calorie, high-salt diet. Applied health studies in exercise physiology, 2022; 9(2): 112-122. doi: 10.22049/jahssp.2022.27852.1477

  • Khani, Mustafa, Zolfi, Hamidreza, Niknam, Jaleh. The effect of two weeks of high intensity interval training (HIIT) with thyme supplementation on lipid profile, oxidative stress, body composition and aerobic capacity in obese and overweight women. Applied health studies in exercise physiology, 2023; 10(2): 27-39. doi: 10.22049/jahssp.2023.28299.1541
  • Falcão-Pires I, Leite-Moreira AF. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail Rev. Springer; 2012;17(3):325–44.
  • Singh VP, Le B, Khode R, Baker KM, Kumar R. Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes. Am Diabetes Assoc; 2008;57(12):3297–306.
  • Nikookheslat Dabbagh S, Novin N, Karimi P. Effect of Six Week High Intensity Interval Training (HIIT) with Chia Seed Supplementation on VEGF and Cardiac Fibrosis in Male Wistar Diabetic [Theses]. 2018;169. (In Persian).
  • Atabakhshian R, Raygan F, Kazerouni F. Galectin-3 in fibrosis and heart failure. Clin Excell. Clinical Excellence; 2014;2(2):36–49.
  • Jiang S, Li T, Yang Z, Yi W, Di S, Sun Y, et al. AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging. Ageing Res Rev. Elsevier; 2017;38:18–27.
  • Daskalopoulos EP, Dufeys C, Bertrand L, Beauloye C, Horman S. AMPK in cardiac fibrosis and repair: actions beyond metabolic regulation. J Mol Cell Cardiol. Elsevier; 2016;91:188–200.
  • Cheng D, Xu Q, Wang Y, Li G, Sun W, Ma D, et al. Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling. J Transl Med. BioMed Central; 2021;19(1):1–18.
  • Zhao Y, Sun D, Chen Y, Zhan K, Meng Q, Zhang X, et al. Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways. Biomed Pharmacother. Elsevier; 2020;130:110522.
  • Woo JH, Shin KO, Lee YH, Jang KS, Bae JY, Roh HT. Effects of treadmill exercise on skeletal muscle mTOR signaling pathway in high-fat diet-induced obese mice. J Phys Ther Sci. The Society of Physical Therapy Science; 2016;28(4):1260–5.
  • Kemi OJ, Ceci M, Wisloff U, Grimaldi S, Gallo P, Smith GL, et al. Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol. Wiley Online Library; 2008;214(2):316–21.
  • Nagata K, Miyachi M, Kato MF, Yazawa H, Ohtake M, Tsuboi K, et al. Exercise Training Alters Left Ventricular Geometry and Improves Heart Failure in Dahl Salt-Sensitive Hypertensive Rats: Role of PI3K p110α/γ-Akt-mTOR-Mediated Activation of Proangiogenic Signaling. Am Heart Assoc; 2008.
  • Holloway TM, Bloemberg D, Da Silva ML, Simpson JA, Quadrilatero J, Spriet LL. High intensity interval and endurance training have opposing effects on markers of heart failure and cardiac remodeling in hypertensive rats. PLoS One. Public Library of Science San Francisco, CA USA; 2015;10(3):e0121138.
  • Rahmani M, Sadeghi A, Pourrazi H, Ghiyami SH. The Effect of Eight-Week High Intensity Interval Training (HIIT) and Caffeine Intake On The p38α and hsp70 Protein expression in liver in Diabetic rats induced streptozotocin. J Appl Heal Stud Sport Physiol. Azarbaijan Shahid Madani University; 2022;9(1):83–99.
  • Gandmani RT, Demirchi A, Mirzaei B. The effect of high and moderate resistance training intensities on the gen expression of AMPK, PGC-1α, TFAM and cytochrome-C of cardiac myocytes in elderly Wistar rats. Iran J Physiol Pharmacol. 2022;6(16):1–9.
  • Wahl P, Bloch W, Proschinger S. The Molecular Signature of High-intensity Training in the Human Body. Int J Sports Med. Georg Thieme Verlag KG; 2022;43(03):195–205.
  • Kido K, Sase K, Yokokawa T, Fujita S. enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mtoR complex 1 inhibition. Sci Rep. Nature Publishing Group; 2020;10(1):1–12.
  • Sun X, Lessard SJ, An D, Koh H, Esumi H, Hirshman MF, et al. Sucrose nonfermenting AMPK‐related kinase (SNARK) regulates exercise‐stimulated and ischemia‐stimulated glucose transport in the heart. J Cell Biochem. Wiley Online Library; 2019;120(1):685–96.
  • Liu H-T, Pan S-S. Late exercise preconditioning promotes autophagy against exhaustive exercise-induced myocardial injury through the activation of the AMPK-mTOR-ULK1 pathway. Biomed Res Int. Hindawi; 2019;2019.
  • Ziemann E, Grzywacz T, Luszczyk M, Laskowski R, Olek RA, Gibson AL. Aerobic and anaerobic changes with high-intensity interval training in active college-aged men. J Strength Cond Res. LWW; 2011;25(4):1104–12.
  • Jokar M, Sherafati Moghadam M, Daryanoosh F. The effect of a period of high-intensity interval training on the content of AMPK and PGC-1α proteins in the heart muscle tissue of rats with type 2 diabetes. Daneshvar Med. Shahed University; 2021;29(1):23–34.
  • Torma F, Gombos Z, Jokai M, Takeda M, Mimura T, Radak Z. High intensity interval training and molecular adaptive response of skeletal muscle. Sport Med Heal Sci. Elsevier; 2019;1(1):24–32.
  • Ghahramani MH, Agha-Alinejhad H, Molanouri Shamsi M. Effect of Different Concurrent Training Protocols on Muscle Strength, Serum Testosterone and Cortisol Level in Young Wrestlers. J Appl Heal Stud Sport Physiol. Azarbaijan Shahid Madani University; 2022;9(1):1–11.
  • Viollet B, Horman S, Leclerc J, Lantier L, Foretz M, Billaud M, et al. AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol. Taylor & Francis; 2010;45(4):276–95.
  • Kundu BK, Zhong M, Sen S, Davogustto G, Keller SR, Taegtmeyer H. Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis. Cardiology. Karger Publishers; 2015;130(4):211–20.
  • Menz V, Marterer N, Amin SB, Faulhaber M, Hansen AB, Lawley JS. Functional vs. Running low-volume high-intensity interval training: Effects on vo2max and muscular endurance. J Sports Sci Med. Dept. of Sports Medicine, Medical Faculty of Uludag University; 2019;18(3):497.
  • Sasidharan SR, Joseph JA, Anandakumar S, Venkatesan V, Ariyattu Madhavan CN, Agarwal A. An experimental approach for selecting appropriate rodent diets for research studies on metabolic disorders. Biomed Res Int. Hindawi; 2013;2013.
  • Brown MB, Neves E, Long G, Graber J, Gladish B, Wiseman A, et al. High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension. Am J Physiol Integr Comp Physiol. American Physiological Society Bethesda, MD; 2017;312(2):R197–210.
  • Bedford TG, Tipton CM, Wilson NC, Oppliger RA, Gisolfi C V. Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol. 1979;47(6):1278–83.
  • PITHON-CURI TNIAC. Aprogram Of Moderate Physical Training For Wistar Rats Based On Maximal Oxygen Consumption. J strength Cond Res. 2007;21(3):0.
  • Liao J, Li Y, Zeng F, Wu Y. Regulation of mTOR pathway in exercise-induced cardiac hypertrophy. Int J Sports Med. © Georg Thieme Verlag KG; 2015;36(05):343–50.
  • Jokar M, Zarei F, Moghadam MS, Palavani HA. Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats. J Shahid Sadoughi Univ Med Sci. 2020;28(6):2755–65. (In Persian).
  • Khalafi M, Mohebbi H, Symonds ME, Karimi P, Akbari A, Tabari E, et al. The impact of moderate-intensity continuous or high-intensity interval training on adipogenesis and browning of subcutaneous adipose tissue in obese male rats. Nutrients. MDPI; 2020;12(4):925.
  • Łukaszuk B, Bialuk I, Górski J, Zajączkiewicz M, Winnicka MM, Chabowski A. A single bout of exercise increases the expression of glucose but not fatty acid transporters in skeletal muscle of IL-6 KO mice. Lipids. Springer; 2012;47(8):763–72.
  • Dela F, Ploug T, Handberg A, Petersen LN, Larsen JJ, Mikines KJ, et al. Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM. Diabetes. Am Diabetes Assoc; 1994;43(7):862–5.
  • Zhu X-J, Chen L-H, Li J-H. The effects of aerobic exercise on plasma adiponectin level and adiponectin-related protein expression in myocardial tissue of ApoE-/-mice. J Sports Sci Med. Dept. of Sports Medicine, Medical Faculty of Uludag University; 2015;14(4):877.
  • Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, et al. Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Sci Rep. Nature Publishing Group; 2017;7(1):1–10.
  • Amri J, Parastesh M, Sadegh M, Latifi SA, Alaee M. High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin. Physiol Int. Akadémiai Kiadó Budapest; 2019;106(3):213–24.
  • Tabari E, Mohebbi H, Karimi P, Moghaddami K, Khalafi M. The effects of interval training intensity on skeletal muscle pgc-1α in type2 diabetic male rats. Iran J Diabetes Metab. Iranian Journal of Diabetes and Metabolism; 2019;18(4):179–88.
  • Mateo-Gallego R, Madinaveitia-Nisarre L, Giné-Gonzalez J, Bea AM, Guerra-Torrecilla L, Baila-Rueda L, et al. The effects of high-intensity interval training on glucose metabolism, cardiorespiratory fitness and weight control in subjects with diabetes: systematic review a meta-analysis. Diabetes Res Clin Pract. Elsevier; 2022;109979.
  • َAzali Alamdari K, Khodaei O. The effect of high intensity interval training on serum adiponectin, insulin resistance and markers of metabolic syndrome in men with metabolic syndrome. J Appl Heal Stud Sport Physiol. Azarbaijan Shahid Madani University; 2018;5(1):69–76.
  • Winding KM, Munch GW, Iepsen UW, Van Hall G, Pedersen BK, Mortensen SP. The effect on glycaemic control of low‐volume high‐intensity interval training versus endurance training in individuals with type 2 diabetes. Diabetes, Obes Metab. Wiley Online Library; 2018;20(5):1131–9.
  • Mahmoudi Y, Gholami M, Nikbakht H, Ebrahim K, Bakhtiyari S. Effect of high intensity interval training with metformin on lipid profiles and HbA1c in diabetic rats. Iran J Diabetes Obes. Iranian Journal of Diabetes and Obesity; 2018;10(3):144–50.
  • Novoa U, Arauna D, Moran M, Nuñez M, Zagmutt S, Saldivia S, et al. High-intensity exercise reduces cardiac fibrosis and hypertrophy but does not restore the nitroso-redox imbalance in diabetic cardiomyopathy. Oxid Med Cell Longev. Hindawi; 2017;2017.
  • Soori R, Amini AA, Choobineh S, Eskandari A, Behjat A, Ghram A, et al. Exercise attenuates myocardial fibrosis and increases angiogenesis-related molecules in the myocardium of aged rats. Arch Physiol Biochem. Taylor & Francis; 2022;128(1):1–6.
  • Shi X, Chen X, Qiu X, Luo W, Luo X, Liu H, et al. Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial. Front Cardiovasc Med. Frontiers Media SA; 2022;9.
  • Mack M. Inflammation and fibrosis. Matrix Biol. Elsevier; 2018;68:106–21.
  • Nishida K, Otsu K. Inflammation and metabolic cardiomyopathy. Cardiovasc Res. Oxford University Press; 2017;113(4):389–98.
  • Han S, Chandel NS. Lessons from cancer metabolism for pulmonary arterial hypertension and fibrosis. Am J Respir Cell Mol Biol. American Thoracic Society; 2021;65(2):134–45.
  • Salvador Jr DB, Gamba MR, Gonzalez-Jaramillo N, Gonzalez-Jaramillo V, Raguindin PFN, Minder B, et al. Diabetes and myocardial fibrosis: a systematic review and meta-analysis. Cardiovasc Imaging. American College of Cardiology Foundation Washington DC; 2022;15(5):796–808.
  • Mellor KM, Bell JR, Young MJ, Ritchie RH, Delbridge LMD. Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J Mol Cell Cardiol. Elsevier; 2011;50(6):1035–43.
  • Hill MA, Yang Y, Zhang L, Sun Z, Jia G, Parrish AR, et al. Insulin resistance, cardiovascular stiffening and cardiovascular disease. Metabolism. Elsevier; 2021;119:154766.
  • Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. Springer; 2018;17(1):1–14.
  • Luneva EB, Vasileva AA, Karelkina E V, Boyarinova MA, Mikhaylov EN, Ryzhkov A V, et al. Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity. J Clin Med. MDPI; 2022;11(10):2843.
  • Zhou G, Sebhat IK, Zhang BB. AMPK activators–potential therapeutics for metabolic and other diseases. Acta Physiol. Wiley Online Library; 2009;196(1):175–90.
  • Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes, Metab Syndr Obes targets Ther. Dove Press; 2014;7:241.
  • Steneberg P, Lindahl E, Dahl U, Lidh E, Straseviciene J, Backlund F, et al. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients. JCI insight. American Society for Clinical Investigation; 2018;3(12).
  • Ma X, Fu Y, Xiao H, Song Y, Chen R, Shen J, et al. Cardiac fibrosis alleviated by exercise training is AMPK-dependent. PLoS One. Public Library of Science San Francisco, CA USA; 2015;10(6):e0129971.
    • Radaei, Zainab, Shameshki, Afsana, Samadi, Ali. The effect of eight weeks of speed interval training (SIT) on the oxidant/antioxidant status of the heart tissue of male Wistar rats fed a high-calorie, high-salt diet. Applied health studies in exercise physiology, 2022; 9(2): 112-122. doi: 10.22049/jahssp.2022.27852.1477

    62. Khani, Mustafa, Zolfi, Hamidreza, Niknam, Jaleh. The effect of two weeks of high intensity interval training (HIIT) with thyme supplementation on lipid profile, oxidative stress, body composition and aerobic capacity in obese and overweight women. Applied health studies in exercise physiology, 2023; 10(2): 27-39. doi: 10.22049/jahssp.2023.28299.1541

  • Hoffman JR, Gepner Y, Stout JR, Hoffman MW, Ben-Dov D, Funk S, et al. β-Hydroxy-β-methylbutyrate attenuates cytokine response during sustained military training. Nutrition research. 2016;36(6):553-63.
  • Smith HJ, Mukerji P, Tisdale MJ. Attenuation of proteasome-induced proteolysis in skeletal muscle by β-hydroxy-β-methylbutyrate in cancer-induced muscle loss. Cancer research. 2005;65(1):277-83.
  • Arazi H, Rohani H, Ghiasi A, Davaran M. The effect of HMB supplementation on cardiovascular risk factors after four weeks of resistance training in amateur athletes. International Cardiovascular Research Journal. 2017;9(2).
  • Willoughby DS, Taylor M, Taylor L. Glucocorticoid receptor and ubiquitin expression after repeated eccentric exercise. Medicine and science in sports and exercise. 2003;35(12):2023-31.
  • Asadi A, Arazi H, Suzuki K. Effects of Nutrients. 2017;9(12):1316.
  • Wilson G, Wilson J, Manninen A. Effects on beta-hydroxy-betamethylbutyrate (HMB) on exercise levels of age, sex and training experience: A review. Nutrition & Metabolism. 2008;5(1):1-10.1186.
  • Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, et al. The role of leucine and its metabolites in protein and energy metabolism. Amino acids. 2016;48:41-51.
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