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خلفی, موسی, آقایی نژاد, مریم, سرسنگی, مریم. (1404). تاثیر تمرین ورزشی بر مقادیر گردش خونی BDNF و IGF-1 در کودکان و نوجوانان: مروری نظام مند با فراتحلیل. , 12(1), 136-154. doi: 10.22049/jahssp.2024.29758.1658
موسی خلفی; مریم آقایی نژاد; مریم سرسنگی. "تاثیر تمرین ورزشی بر مقادیر گردش خونی BDNF و IGF-1 در کودکان و نوجوانان: مروری نظام مند با فراتحلیل". , 12, 1, 1404, 136-154. doi: 10.22049/jahssp.2024.29758.1658
خلفی, موسی, آقایی نژاد, مریم, سرسنگی, مریم. (1404). 'تاثیر تمرین ورزشی بر مقادیر گردش خونی BDNF و IGF-1 در کودکان و نوجوانان: مروری نظام مند با فراتحلیل', , 12(1), pp. 136-154. doi: 10.22049/jahssp.2024.29758.1658
خلفی, موسی, آقایی نژاد, مریم, سرسنگی, مریم. تاثیر تمرین ورزشی بر مقادیر گردش خونی BDNF و IGF-1 در کودکان و نوجوانان: مروری نظام مند با فراتحلیل. , 1404; 12(1): 136-154. doi: 10.22049/jahssp.2024.29758.1658

تاثیر تمرین ورزشی بر مقادیر گردش خونی BDNF و IGF-1 در کودکان و نوجوانان: مروری نظام مند با فراتحلیل

مطالعات کاربردی تندرستی در فیزیولوژی ورزش
مقاله 11، دوره 12، شماره 1، فروردین 1404، صفحه 136-154    اصل مقاله (948.27 K)
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
شناسه دیجیتال (DOI): 10.22049/jahssp.2024.29758.1658
نویسندگان
موسی خلفی* 1؛ مریم آقایی نژاد2؛ مریم سرسنگی2
1گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه کاشان، کاشان، ایران
2گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه کاشان، کاشان، ایران
چکیده
هدف. اثر تمرین ورزشی بر این بیوماکرهای محافظت کننده عصبی شامل عامل رشد عصبی مشتق شده از مغز (BDNF) و عامل رشد شبه انسولینی ( IGF-1) در کودکان و نوجوانان به صورت متناقض گزارش شده است. از این‌رو، هدف فراتحلیل حاضر بررسی تاثیر تمرین ورزشی بر مقادیر گردشی خونی BDNF و IGF-1 در کودکان و نوجوانان می باشد.
روش پژوهش. جست‌وجوی جامع در پایگاه های اطلاعاتی PubMed، Web of Science، Scopus و Google Scholar و همچنین پایگاه های ایرانی بدون محدودت زمانی برای شروع تا تاریخ ۱۵ آذر ماه ۱۴۰۲ انجام شد. معیارهای ورود به مطالعه حاضر براساس دستورالعمل PICOS (جمعیت، مداخله، مقایسه، متغیر و نوع مطالعه) شامل : ۱) کودکان و نوجوانان، 2) تمرینات ورزشی منظم با طول مداخله بیش از 2 هفته، 3) مطالعات دارای گروه شاهد یا مقادیر اندازه گیری شده در مرحله پیش آزمون، 4) BDNF، IGF-1 اندازه گیری شده در گردش خون (سرم و پلاسما) و 5) مطالعات تک گروهی (بدون گروه کنترل) و دو گروهی ( دارای گروه کنترل) بودند. برای تعیین اندازه اثر، SMD و فاصله اطمینان ۹۵ درصد (CIs) با استفاده از مدل تصادفی محاسبه شد. یافته ها. در مجموع 21 مطالعه شامل  855 آزمودنی کودک و نوجوان با میانگین سنی 7 تا 17 سال وارد فراتحلیل حاضر شدند. بر اساس نتایج فراتحلیل، تمرین ورزشی منجر به افزایش معنی دار سطوح BDNF با اندازه اثر متوسط می‌شود ] 01/0 = P، (91/0 الی 11/0 : Cl ) 51/0 = SMD [. با این وجود، تمرین ورزشی اثر معنی داری بر سطوح IGF-1 نداشت ] 17/۰ = P، ( 61/۰ الی 11/۰- :Cl ) 25/0 = SMD [. نتیجه گیری. تمرین ورزشی ممکن است به واسطه افزایش BDNF منجر به اثرات مفید در بهبود عملکرد شناختی و همچنین وضعیت متابولیکی کودکان و نوجوانان گردد. با این وجود، تمرین ورزشی اثرات قابل توجهی بر IGF-1 نداشت و لازم است پاسخ این هورمون به فعالیت ورزشی بیشتر بررسی شود.
کلیدواژه‌ها
تمرین ورزشی؛ BDNF؛ IGF-1؛ کودکان؛ نوجوانان
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